What type of condition is asthma?
A chronic inflammatory condition of the respiratory mucosa.
What causes breathing attacks in asthma?
Narrowing of the respiratory passageways.
What three conditions make up the atopic triad?
Asthma, atopic dermatitis, and atopic rhinitis.
What does the hygiene hypothesis propose about asthma susceptibility?
Reduced pathogen exposure increases asthma susceptibility by altering leukocyte maturation.
Asthma Type
Chronic inflammatory respiratory condition
Hygiene hypothesis
Reduced pathogen exposure increases asthma susceptibility
Samter's triad
Asthma, nasal polyps, ASA sensitivity
ASA Sensitivity Pathway
COX inhibition increases leukotrienes, causing bronchospasms
Leukotrienes role
Cause bronchospasms, increase vascular permeability, mucus
Allergen recognition
Dendritic cells present allergen to Th2 cells via MHC-II
IgE activation
Binds to mast cells, causing degranulation and mediator release
Answer 10 questions on Asthma Pathophysiology.
1. Which feature most completely defines asthma?
2. A patient experiences one brief episode of airway narrowing but has no evidence of chronic respiratory inflammation. Why should this episode not by itself be classified as asthma?
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