Cancer hallmarks — definition?
Biological traits enabling tumor growth and spread.
Cell cycle dysregulation — mechanism?
Mutations in genes controlling cell division lead to uncontrolled proliferation.
Tumor microenvironment — components?
Includes stromal cells, immune cells, ECM, and signaling molecules.
Cancer hallmarks — definition?
Biological capabilities enabling tumor growth and spread.
Sustaining proliferative signaling — role?
Allows continuous growth stimulation in cancer cells.
Evading growth suppressors — example?
Inactivation of p53 or RB.
Resisting cell death — mechanism?
Avoiding apoptosis through pathway mutations.
Enabling replicative immortality — factor?
Telomerase activation maintains telomeres.
Angiogenesis — process?
Tumors stimulate new blood vessel formation.
Invasion and metastasis — ability?
Cancer spreads to distant sites.
Answer 10 questions on Cancer Biology Essentials.
1. What are the 'Hallmarks of Cancer' as described in cancer biology?
2. Which gene is most commonly associated with cell cycle regulation dysregulation in cancer?
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