Immune system organization — main components?
Innate and adaptive immunity
Cellular actors — key lymphocytes?
B cells, T cells, NK cells
Pathogen recognition — primary molecules?
Antigens and pattern recognition receptors
Innate immunity components?
Physical barriers, phagocytes, complement, PRRs
Adaptive immunity components?
B cells, T cells, antibodies, MHC molecules
Cell signaling — key molecules?
Receptors, cytokines, second messengers
Lymphocyte development — primary organs?
Bone marrow (B cells), thymus (T cells)
Antigen recognition — main process?
Receptors bind specific epitopes on antigens
Historical vaccination — key discovery?
Edward Jenner's smallpox vaccine (1796)
Immunological techniques — common method?
ELISA for detecting antigens or antibodies
Innate immunity — recognition mechanism?
PRRs detect PAMPs and DAMPs
Adaptive immunity — recognition mechanism?
BCRs and TCRs recognize specific epitopes
Pathogen recognition — innate vs adaptive?
Innate: PAMPs; Adaptive: specific epitopes
Lymphocyte maturation site — B cells?
Bone marrow
Lymphocyte maturation site — T cells?
Thymus
Antigen presentation — key molecules?
MHC class I and II
V(D)J recombination — purpose?
Generate receptor diversity
Clonal selection — process?
Proliferation of specific lymphocytes upon antigen recognition
Answer 10 questions on Fundamentals of Immunology.
1. What does the term 'immune system organization' refer to?
2. Who is the author credited with developing the first successful smallpox vaccine in 1796?
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