Genetic accidents — role?
Cause tumor heterogeneity and variation.
Clone — definition?
Group of cells from a single ancestor.
Mutations — effect?
Create genetic diversity within clones.
Clone — definition?
Cells derived from a single ancestor, mostly identical.
Mitotic replication — role?
Duplicates DNA before cell division.
Genetic stability — importance?
Maintains consistent genome across cell generations.
Mutations — effect on clones?
Create genetic diversity within a clone.
Sub-clone — origin?
Arises from mutations within a clone.
Genetic accident — example?
Mutation or chromosomal aberration during division.
Mutations in tumors — consequence?
Cause heterogeneity, affecting gene regulation.
Answer 9 questions on Genetic Reproduction and Diversity.
1. How do genetic accidents differ from crossing-over and recombination in terms of their roles in genetic variation and stability?
2. What does the term 'genetic clone stability' primarily refer to in cellular biology?
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