Complement system — overview?
Innate immunity component that enhances immune responses.
Activation pathways — types?
Classical, lectin, and alternative pathways.
Effector functions — main?
Lysis, opsonization, inflammation promotion.
Regulation mechanisms — purpose?
Prevent host tissue damage from overactivation.
Classical pathway — trigger?
Antigen-antibody complexes.
Lectin pathway — trigger?
Mannose-binding lectin binding to microbes.
Alternative pathway — trigger?
Spontaneous C3 hydrolysis on microbial surfaces.
Membrane attack complex — role?
Lyses target cell membranes.
C3b — function?
Opsonizes pathogens for phagocytosis.
C5a — role?
Recruits and activates immune cells, promotes inflammation.
Answer 5 questions on Understanding the Complement System in Immunity.
1. Which of the following is a key component of the regulation mechanisms in the complement system?
2. What is the complement system primarily understood as in innate immunity?
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