Cell Injury and Death Mechanisms

From the study guide

Course Outline

  1. Cell responses to stress and injury
  2. Causes of cell injury
  3. Reversible injury and cell death
  4. Necrosis patterns and biomarkers
  5. Apoptosis pathways and morphology
  6. Autophagy and necroptosis
  7. Oxidative stress and membrane damage
  8. Hypoxia and reperfusion injury
  9. Chemical, infectious, and immune injury
  10. Cellular adaptations to stress
  11. Intracellular accumulations and pigments
  12. Calcification and cellular aging

1. Cell responses to stress and injury

Key Concepts & Definitions

  • Homeostasis: Homeostasis is the steady functional state that a normal cell maintains despite physiologic demands and constraints from its surroundings.
  • Adaptation: Adaptation is a reversible change in function and structure that lets a cell survive a stress when limits are not exceeded.
  • Cell injury: Cell injury is the progression of cellular dysfunction that occurs when stress exceeds adaptive limits, critical nutrients are lacking, or essential functions are impaired.
  • Reversible cell injury: Reversible cell injury is early or mild damage where structural and functional alterations can be corrected if the injurious stimulus stops.
  • Irreversible injury: Irreversible injury is persistent or severe damage that passes beyond a repair limit and leads to cell death.

Essential Points

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Practice quiz preview

1. What is the best term for a reversible change in cell structure and function that helps a cell survive a stress when adaptive limits are not exceeded?

2. Which sequence best describes what happens when a stress is removed before damage becomes severe?

3. Which condition is an example of oxygen deprivation causing cell injury by reducing aerobic oxidative respiration?

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Flashcard preview

Homeostasis — definition?

Steady functional state of a cell.

Adaptation — role?

Reversible cellular changes to survive stress.

Cell injury — triggers?

Exceeds adaptive limits, nutrient deficiency, or function impairment.

Reversible injury — hallmark?

Cell swelling and hydropic change.

Irreversible injury — key feature?

Severe membrane damage and mitochondrial failure.

Necrosis pattern — coagulative?

Architecture preserved, seen in infarcts.

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