Genetics Fundamentals: Inheritance and Variation

From the study guide

Course Outline

  1. Single-gene inheritance variations
  2. Protein function and dominance
  3. Multiple alleles and phenotype diversity
  4. Incomplete dominance
  5. Codominance and ABO blood groups
  6. Lethal alleles
  7. Pedigrees and inheritance patterns
  8. Product rule in genetics

1. Single-gene inheritance variations

Key Concepts & Definitions

  • Multiple allelism: Multiple allelism is when a gene locus has more than two possible alleles in a population.
  • Incomplete dominance: Incomplete dominance is a single-gene pattern where the heterozygote shows an intermediate phenotype between the two homozygotes.
  • Codominance: Codominance is a single-gene pattern where a heterozygote expresses both alleles simultaneously without an intermediate phenotype.
  • Lethal alleles: Lethal alleles are gene variants whose homozygous state causes death, while the heterozygous state can be viable.
  • Pedigrees: Pedigrees are family trees that track the segregation of a trait across multiple generations to infer inheritance patterns.

Essential Points

  • In a population, more than two alleles can exist at a single gene locus even though each individual carries only two alleles per gene.
  • Many distinct phenotypes can arise from multiple alleles at one locus in the population.
  • For interpretation, common phenotypic ratios include 3:1, 1:2:1, 2:1, and the “2:1” shift caused by lethal genotypes.

Memory Hook

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Practice quiz preview

1. What best describes multiple allelism at a gene locus?

2. In a single-gene lethal-allele scenario, why can an expected 3:1 offspring ratio shift to 2:1?

3. What amount of functional protein is associated with the dominant phenotype in the simple example of protein P?

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Flashcard preview

Single-gene variations — types?

Incomplete dominance, codominance, lethal alleles, multiple alleles.

Protein dominance — threshold?

≥50% functional protein causes dominant phenotype.

Multiple alleles concept

More than two alleles possible at one gene locus.

Incomplete dominance

Intermediate phenotype in heterozygotes.

Codominance example

Both alleles expressed in heterozygotes.

Lethal alleles

Homozygous can cause death, heterozygous viable.

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