Folate antagonists — role?
Inhibit DHFR, block DNA synthesis
Topoisomerase II — function?
Relaxes DNA during replication and transcription
P-glycoprotein — mechanism?
Efflux pump reducing intracellular drug concentration
Cell cycle phases — target of agents?
Mainly S-phase
Main drug classes — examples?
Antimetabolites, alkylating agents, antibiotics, microtubule inhibitors
Folate antagonists — function?
Inhibit DHFR, block nucleotide synthesis
Alkylating agents — DNA effect?
Form covalent crosslinks, cause DNA damage
P-glycoprotein — role?
Efflux transporter, causes drug resistance
Microtubule inhibitors — arrest at?
Metaphase during mitosis
Multidrug resistance — mechanism?
P-gp efflux, reduced drug uptake, increased repair
Answer 9 questions on Classical Anticancer Agents Overview.
1. Which feature distinguishes taxanes from vinca alkaloids in their mechanism of microtubule inhibition?
2. What is the main mechanism by which alkylating agents cause damage to DNA in cancer cells?
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