CO — binding to hemoglobin?
Reversibly binds, displacing oxygen
CO toxicity — mechanism?
HbCO formation causes hypoxia and mitochondrial inhibition
Organophosphates — action?
Inhibit cholinesterases, causing cholinergic crisis
CO poisoning — primary cause?
Inhalation of incomplete combustion gases.
HbCO levels indicating intoxication?
Above 15%; >50% often fatal.
Organophosphates — mechanism?
Irreversibly inhibit acetylcholinesterase.
Cholinesterase activity — significance?
Confirms organophosphate poisoning.
Psychotropic overdose — systems affected?
CNS, cardiovascular, respiratory.
CO affinity for hemoglobin?
200-250 times that of O2.
Antidotes for organophosphates?
Atropine + pralidoxime.
Answer 9 questions on Toxicology of Carbon Monoxide, Organophosphates, and Psychotropes.
1. What is the primary mechanism by which carbon monoxide (CO) causes toxicity in the human body?
2. Which of the following clinical signs is most characteristic of organophosphate poisoning?
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