1. Which of the following is a key risk factor that contributes to endothelial dysfunction in the development of atherosclerosis?
2. How does LDL oxidation contribute to monocyte attraction in the development of atherosclerosis?
3. What is the primary cellular process involved in the formation of foam cells during atherosclerosis?
Endothelial dysfunction — role?
Initiates atherosclerosis by increasing permeability and adhesion.
LDL oxidation — consequence?
Promotes monocyte attraction and foam cell formation.
Foam cells — origin?
Macrophages ingest oxidized LDL.
Fatty streaks — first lesion?
Early accumulation of foam cells in arterial wall.
Fibrous plaque — composition?
Smooth muscle, collagen, lipid core.
Plaque stability — high collagen content?
Leads to stable, less rupture-prone plaque.
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