1. Which process primarily initiates endothelial dysfunction that leads to LDL oxidation in atherosclerosis?
2. What is the initial cellular event in the formation of a fatty streak during atherosclerosis development?
3. What is the primary role of collagen production in the development of a fibrous plaque during atherosclerosis?
Endothelial Dysfunction — role?
Initiates atherogenesis by increasing permeability.
LDL oxidation — process?
LDL crosses endothelium and oxidizes beneath it.
Fatty streak — composition?
Accumulation of foam cells from monocytes.
Monocyte transformation — role?
Monocytes become foam cells in fatty streaks.
Fibrous plaque — features?
VSMC migration, collagen synthesis, extracellular lipid.
Collagen production — source?
Vascular smooth muscle cells.
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