Pathology of Tumors and Glomerulonephritis

From the study guide

Course Outline

  1. Glomerulonephritis Types
  2. Tumor Markers
  3. Lymphoma Subtypes
  4. Breast Cancer Features
  5. Ovarian Tumors
  6. Renal Pathologies
  7. Neoplastic Lesions
  8. Histological Features
  9. Genetic Abnormalities
  10. Tumor Staging

1. Glomerulonephritis Types

Key Concepts & Definitions

  • Membranous glomerulonephritis (characterized by electron-dense thickening of the glomerular basement membrane due to complement deposition). This thickening results from immune complex deposits on the subepithelial side of the basement membrane, leading to a "spike and dome" appearance (formation of basement membrane spikes in membranous glomerulonephritis).
  • Membranoproliferative glomerulonephritis (MPGN) Types I and II: Distinct forms of immune complex-mediated glomerulonephritis. Type I involves subendothelial immune deposits, while Type II (also called dense deposit disease) features intramembranous dense deposits within the basement membrane, often associated with complement activation (see authors for detailed classification).
  • IgA nephropathy (also known as Berger's disease): Features mesangial IgA deposits seen on immunofluorescence, with complement activation playing a role. It is the most common form of primary glomerulonephritis worldwide and involves immune complex deposition predominantly in the mesangium, leading to mesangial proliferation.
  • Primary vs secondary glomerulopathies: Primary…
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Practice quiz preview

1. What is membranous glomerulonephritis primarily characterized by?

2. Which genetic translocation is associated with bcl-2 overexpression in follicular lymphoma?

3. What is the primary role of specific genetic translocations such as t(11;14) and t(2;5) in lymphoma subtypes?

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Flashcard preview

Glomerulonephritis types — main categories?

Membranous, MPGN, IgA nephropathy, primary and secondary.

Membranous GN — characteristic feature?

Electron-dense basement membrane thickening with spikes.

MPGN Types I & II — deposit location?

Type I: subendothelial; Type II: intramembranous dense deposits.

IgA nephropathy — deposits?

Mesangial IgA deposits with complement activation.

Primary vs secondary GN — difference?

Primary: intrinsic; secondary: systemic disease causes.

Basement membrane spikes — seen in?

Membranous glomerulonephritis.

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