Glomerulonephritis types — main categories?
Membranous, MPGN, IgA nephropathy, primary and secondary.
Membranous GN — characteristic feature?
Electron-dense basement membrane thickening with spikes.
MPGN Types I & II — deposit location?
Type I: subendothelial; Type II: intramembranous dense deposits.
IgA nephropathy — deposits?
Mesangial IgA deposits with complement activation.
Primary vs secondary GN — difference?
Primary: intrinsic; secondary: systemic disease causes.
Basement membrane spikes — seen in?
Membranous glomerulonephritis.
t(10;18) translocation — associated lymphoma?
Follicular lymphoma, causes Bcl-2 overexpression.
Sezary syndrome cells — immunophenotype?
CD2+, CD3+, CD4+, CD7-.
HER2/neu — role in breast cancer?
Prognostic marker and therapeutic target.
HPV-12 — associated lesion?
Verruca (wart).
t(2;5)(p23;q35) — lymphoma?
Anaplastic large cell lymphoma (ALK fusion).
Mantle cell lymphoma — markers?
CD20+, CD5+, cyclin D1+; t(11;14).
ALCL — genetic feature?
t(2;5)(p23;q35), ALK fusion gene.
Reactive lymph node features?
Hyperplastic germinal centers, granulomas.
Membranous GN — immune deposits?
Subepithelial immune complexes.
MPGN — complement involvement?
Yes, especially in Type II (dense deposit disease).
IgA nephropathy — clinical trigger?
Mucosal infections causing episodic hematuria.
Tumor staging — purpose?
Guide prognosis and treatment based on extent.
pT3b N1 — indicates?
Deep invasion and regional lymph node metastasis.
Histological grading in breast carcinoma?
G1: well-differentiated; G2: moderate; G3: poor.
Answer 10 questions on Pathology of Tumors and Glomerulonephritis.
1. What is membranous glomerulonephritis primarily characterized by?
2. Which genetic translocation is associated with bcl-2 overexpression in follicular lymphoma?
Go over the full study guide for Pathology of Tumors and Glomerulonephritis.
Read the study guide →Anatomie
Physiologie
Physiologie
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